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Molecular diagnostics and point-of-care (POC) testing often rely on fluorescence-based assays for detection and quantification of biomarkers used for identifying pathogens and viral load monitoring.

ZEONOR® Cyclo Olefin Polymer (COP) offers the combination of unsurpassed low fluorescence, high optical transmission, high purity and precision moldability, promoting improved fluorescence-based in-vitro diagnostic device capability.

Microfluidics and flow cell: Precision-molded ZEONOR Cyclo Olefin Polymer (COP) and high-quality ZeonorFilm™ are the building blocks in creating fluidic-based consumables for use in applications such as digital polymerase chain reaction (dPCR) and rapid pathogen detection.

Cell culture and well plates: The inert chemistry and high purity of Cyclo Olefin Polymer (COP) offer an exceptional platform for which cell growth and cell-based assays can be performed.

A broad range of ZEONOR Cyclo Olefin Polymer (COP) and ZeonorFilm grades are available.
 
TechConnect

TechConnect puts you in direct contact with a ZEON engineer who has the expertise in life-science applications to answer your technical questions and suggest which Cyclo Olefin Polymer (COP) grade will work best to meet your product needs.

The Lowest Autofluorescent Injection-Moldable Plastic

Low Autofluorescence

ZEONOR Cyclo Olefin Polymer (COP) offers the lowest fluorescence of any injection-moldable thermoplastic, and is a suitable replacement for glass when moving from lab scale to production scale or when performance improvement is needed with your current plastic.

Fluorescence Spectrum (emission, excitation) comparison: ZEONOR (lowest), Cyclo Olefin Copolymer (COC), Polystyrene.


Fluorescence Spectrum (emission, excitation) comparison: ZEONOR (lowest), Cyclo Olefin Copolymer (COC), Polystyrene.

Glass-Like Optical Properties

ZEONOR optical polymers exhibit glass-like transparency from UVA through near-infrared (NIR) wavelengths.


Low Moisture Permeation

ZEONOR Cyclo Olefin Polymer (COP) is a better barrier to moisture permeation compared to conventional plastics, which promotes stability of reagent concentrations and longer device shelf life of moisture-sensitive compounds.

Inert/Nonreactive Surface

The low surface energy and hydrophobic nature of ZEONOR Cyclo Olefin Polymer (COP) contribute to very low protein binding for improved PCR and flow cytometry efficiency. When surface functionality is desired, the ZEONOR Cyclo Olefin Polymer (COP) surface can be activated using standard industry practices, such as corona or plasma treatment.

High Molding Precision

Microfluidic devices require precise and consistent replication of fluidic channels, posts and other microstructures for proper function and liquid transport. Maintaining a high degree of flatness is critical for imaging applications and device assembly. ZEONOR Cyclo Olefin Polymer (COP) is able to achieve greater resolution and repeatability in mold replication than are other plastics.

High Purity

ZEONOR Cyclo Olefin Polymer (COP) is an extremely pure resin containing less-than-detectable residual metals and no low-molecular-weight additives or process aides. Compared with conventional polymers, assay reagents stored in devices made from Cyclo Olefin Polymer (COP) have low risk of contamination from leaching, offgassing or extractables.

Chemical Resistance

ZEONOR Cyclo Olefin Polymer (COP) demonstrates excellent chemical compatibility with most reagents used in diagnostic reactions.

Acids (HCl, HNO3, H2SO4) Good
Bases (NaOH, NH4) Good
DMSO Good
Hydrogen Peroxide Good
Ethylene Oxide Good
Polar Solvent (IPA, MeOH, EtOH, acetone) Good
Nonpolar Solvent (hexane, toluene, limonene) Poor
Hydrocarbon Oil Poor
Fluorinated Oil Good
Silicone Oil Good

ZeonorFilm

In addition to ZEONOR Cyclo Olefin Polymer (COP) resin, ZEON manufactures high-quality Cyclo Olefin Polymer (COP)-based optical films. They provide the same chemical and optical advantages offered by ZEONOR Cyclo Olefin Polymer (COP) resin. ZeonorFilm is well suited for use in both imaging applications and sealing Cyclo Olefin Polymer (COP)-based fluidic devices. ZeonorFilm is offered in a range of standard thicknesses, from 13 microns to 188 microns.

ZEONEX/ZEONOR Grade Review for Diagnostic Applications

Suggested COP grades for diagnostic consumable Glass Transition Temperature (°C) Melt Flow (g/10min) Notes MSDS
ZEONEX 5000* 69 ~50 Low fluorescence, low Tg, high flow grade  MSDS for Zeonex 5000
ZEONOR 1060R 100 60 Low fluorescence, high flow grade  MSDS for Zeonor 1060R
ZEONOR 1420R 136 20 Low fluorescence, most common grade for PCR  MSDS for Zeonor 1420R
ZEONOR 1430R 136 30 Similar to 1420R, higher flow grade  MSDS for Zeonor 1430R
ZEONEX 330R 120 20 Low fluorescence optical lens grade with lowest birefringence  MSDS for Zeonex 330R
ZEONEX 480 138 20 Low fluorescence optical lens grade  MSDS for Zeonex 480
ZeonorFilm ZF14-series 134 -- Optical film.  Available from 13 ~ 188 micron thickness  MSDS for ZF Film Series
ZeonorFilm ZF16-series 163 -- Optical film.  Available in 50 and 100 micron thickness  MSDS for ZF Film Series
*Tested by ZEON to pass USP class VI and ISO 10993 qualifications; DMF registered.

TechConnect puts you in direct contact with a ZEON engineer who has the expertise in life-science applications to answer your technical questions and suggest which Cyclo Olefin Polymer (COP) grade will work best to meet your product needs.

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