High Purity/Low Offgassing
ZEONEX Cyclo Olefin Polymer (COP) medical grades are an extremely pure resin containing less-than-detectable residual metals or process aides. Compared with conventional barrier polymers, pharmaceuticals packaged using ZEONEX Cyclo Olefin Polymer
(COP) have significantly reduced risk of contamination from off-gassing or extractables.
Low Protein Adsorption
ZEONEX Cyclo Olefin Polymer (COP) is optimal for long-term storage of protein- and peptide-based drugs where there is concern of protein adsorption, as found with glass and polypropylene (PP). ZEONEX Cyclo Olefin Polymer (COP) does not contribute
to the pH shift of the diluent, often observed with glass, thus reducing the chance of protein agglomeration.
Glass-Like Transparency
The ability to visually check the level and quality of drugs during quality inspection and injection/dispensing is critical. ZEONEX Cyclo Olefin Polymer (COP) provides high clarity and low haze for crystal-clear viewing of package contents,
or, when used in multilayer packaging, can help improve the optical characteristics of the package.
Low Moisture Permeation
ZEONEX Cyclo Olefin Polymer (COP) has high moisture barrier property compared with that of conventional polymers, which promotes stability of reagent concentrations and provides longer device shelf life of moisture-sensitive compounds.
High-Precision Molding
ZEONEX Cyclo Olefin Polymer (COP) is suitable for use in precision injection-molded applications such as syringes and other drug delivery devices for prefilled
drug storage. And, for vials and bottles, ZEONEX Cyclo Olefin Polymer (COP) is suitable for blow-molded packaging using conventional molding equipment.
Sterilization-Compatible
ZEONEX is compatible with all conventional means of sterilization, with little impact to mechanical properties.
| ZEONEX Cyclo Olefin Polymer |
Unit |
Initial |
Steam |
EOG |
Gamma |
EB |
| Light transmission |
%, 3mm |
91.7 |
92.1 |
91.9 |
87.1 |
88.1 |
| Yellow index |
|
0.37 |
0.47 |
0.49 |
2.45 |
1.64 |
| Haze |
% |
0.4 |
0.4 |
0.5 |
0.4 |
0.4 |
| DuPont® impact test |
J |
21.7 |
20 |
23.7 |
22.7 |
22.7 |
| Tensile strength |
MPa |
63 |
70 |
63 |
63 |
63 |
| Tensile elongation |
% |
100 |
50 |
100 |
100 |
100 |
Steam sterilization resistance of ZEONEX Cyclo Olefin Polymer
| ZEONEX 690R |
Initial |
1 cycle |
3 cycles |
5 cycles |
| % Transmission |
91.7 |
92.1 |
92 |
91.6 |
| Yellow Index |
0.4 |
0.4 |
0.5 |
0.7 |
| % Haze |
0.37 |
0.47 |
0.69 |
1.04 |
Break-Resistant
ZEONEX Cyclo Olefin Polymer (COP) is ideal for drug storage devices for which there is risk of breakage during filling, transit or use. Break-resistance of Cyclo Olefin Polymer (COP) is maintained at cold storage temperatures.
