BIO-DIAGNOSTIC Applications

LIGHT TRANSMITTANCE

ZEONOR COP resins have superior light transmission from 300-1200nm, as compared to PC and PMMA.

LOW WATER ABSORPTION

ZEONOR’s extremely low water absorption allows compounds to be stored for longer periods of time as compared to devices manufactured from other competitive resins such as PC, PET, and PMMA. ZEONOR’s barrier properties provide for consistent reagent concentrations when operating with extremely low volumetric quantities.

FLUORESCENCE

ZEONOR COP offers extremely low fluorescence across the excitation/emission spectrum. COP has been proven to increase resolution and lower detection limits in fluorescence spectroscopy for in vitro and in vivo imaging.

STERILIZATION

Physical and mechanical properties of devices made from ZEONOR exhibit no significant change after either steam, ethylene oxide or gamma sterilization, especially when compared to other competitive resins.

INERT/NON-REACTIVE SURFACE

ZEONOR’s low surface energy and corresponding hydrophobic nature contribute to very low protein binding, maintaining content homogeneity for use in areas such as flow cytometry and microfluidics.

When cell binding is desired, such as with cell culture plates, ZEONOR can easily be surface activated using standard corona discharge or similar practices. Surface treatment quickly renders ZEONOR with a user-controlled, hydrophilic surface with no loss in optical or mechanical properties.

SUPERIOR MOLDABILITY

ZEONOR COP can be molded into intricately designed devices with detailed micro-features, while offering a broader process window and more ductility than other competitive cyclo-olefin products. ZEONOR exhibits excellent cavity release properties without the need for additives such as lubricants and release agents. High transcription and low shrink allow critical tolerances and a high degree of flatness to be maintained.

FILM

ZeonorFilm® is also available which possesses the same chemical compatibilities, low fluorescence, and excellent optical isotropy provided by ZEONOR resin. This film can be utilized for the sealing of COP substrates for use in film bottom well plates, fluidic devices, and plate top seals. ZeonorFilm also has the capacity for microstructuring via lithography and hot embossing, which can then be laminated to form fluidic devices. These fluidics are well suited for use in research environments for genome sequencing, as well as point of care (POC) applications for disease detection.

For additional information on ZeonorFilm : (http://www.zeonex.com/applications_zeonorfilm.asp)

CHEMICAL RESISTANCE

ZEONOR demonstrates excellent resistance to most diagnostic reagents, including alcohols and DMSO, along with various other aqueous and polar organic solutions.

Rating:
Alcohol	Methanol	O
	Ethanol	O
	IPA (isopropyl alcohol)	O
Ketone	Acetone	O
	MEK (methyl ethyl ketone)	O
	Cyclohexanone	X
	MIBK (methyl isobutyl ketone)	X
Ether	Ethyl ether	X
	THF (tetrahydrofuran)	X
Aromatic series	Xylene	X
Carbon hydride	n-pentane	X
	n-hexane	X
	n-octane	X
Chloride based	1,2-dichloroethane	X
Other solvents	DMSO (Dimethyl Sulfoxide)	O
	DOP (dioctyl phthalate)	X
	DMF (dimethylformamide)	O
	Methyl cellosolve	O
	Limonene	X
Acids	Hydrochloric acid (10%)	O
	Concentrated hydrochloric acid	O
	Sulfuric acid (10%)	O
	Concentrated sulfuric acid	X
	Acetic acid	O
	Formic acid	O
	Nitric acid	O
	Phosphoric acid	O
	Hydrofluoric acid (7%), nitric acid (42%), pure water (51%)	O
Alkali	Caustic soda (50%)	O
	Ammonia water (10%)	O
Other chemicals	Formaldehyde (40%)	O
	Hydrogen peroxide solution (30%)	O

Rating:
Marginal Stress
140 Kgf/cm² or more: O (usable)
100-140 Kgf/cm²: ^ (Exercise caution with use.)
Less than 100 Kgf/cm²: X (unusable)